Ankle Sprain: An ankle sprain is a twisting of the ankle causing a partial or complete tear of the ligaments that hold the ankle together. The severity of the sprain usually dictates treatment. Improper care following an ankle sprain can lead to a more severe injury and potential healing problems. If you sprain your ankle, immobilize the involved area, apply ice and seek professional medical care for a thorough evaluation. Treatment of ankle sprains may involve splinting, cast immobilization, physical therapy, and in severe cases surgery.